and the Wallace H. Coulter School of Engineering Co-Sponsor Shipley
Professor Gabor A. Somorjai, of the Department of Chemistry at the
University of California - Berkeley, presented Shipley Lectures
at Clarkson University on October 21, 2002 and October 22, 2002.
Professor Somorjai is considered the father of modern surface chemistry.
He was one of fifteen scientists named by President George W. Bush
as recipients of the 2002 National Medal of Science, the Nation's
highest honor for lifetime achievement in fields of scientific research.
Professor Somorjai's Shipley presentations included "Surfaces: Favorite
Media of Evolution and New Technologies," and "The Evolution of
Surface Chemistry and Catalysis from the Time of Langmuir and Taylor
to the 21st Century." These lectures were co-sponsored by CAMP and
the Wallace H. Coulter School of Engineering.
left: Clarkson University Provost Anthony Collins, University
Professor Gabor A. Somorjai (University of California at Berkeley),
Clarkson University President Denny Brown, and Professor Egon
Matijevic' (the Victor K. LaMer Chair in Colloid and Surface Science).
Professor Gabor Somorjai (right) converses with Clarkson University
Provost Anthony Collins (left) and Clarkson University Vice Provost
/CAMP Director S.V. Babu (center).
are also being collected on the effect of complexation on the shifts
in carbon NMR peaks. Powell, with the help of Doctors William Lenhart
and Brian Antalek at Eastman Kodak Company (a CAMP corporate Sponsor),
carried out the preliminary experiments which showed the direction
and magnitude of the shifts due to complexation of the carboxamide
receptor mentioned above with donor 2,6-dimethylaniline (2,6-DMA),
the latter being a model compound for toxic bupivacaine (cf.
Fig 1). The data shows that the changes in chemical shifts
upon complexation are dependent on donor concentration; and, the
changes are not the same for the different carbons in either the
acceptor or donor (Table 2). The carbon
atom positions listed in the Table are shown in Figure
2. It is interesting to note that the effect of donor concentration
on the change in chemical shift of the carbonyl carbon in the receptor
is three times the effect on other carbons in the molecule. Binding
energies using the shifts for each carbon, calculated by a method
published previously by others, ranged from -1500 to -3600 J/mol.
An example of a plot is shown in Figure 3.
researchers will obtain more detailed NMR information on these chemical
systems using both Kodak and Clarkson/CAMP instrumentation with
the goal of comparing the shift data to uptake of a toxin as measured
by HPLC or other analytical method. Ultimately it is hoped that
some deduction can be made as to what the preferred rotational configuration
the two rings shown in Figure 2 might
have with respect to each other, and why the changes in shifts differ
for the carbon atoms in both the acceptor and donor molecules.
more information about Professor Partch and his research, please
call him at 315-268-2351 or send email to firstname.lastname@example.org.