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CAMP Annual Report: Page 9

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Research Activities Carried out By Professor Evgeny Katz and His Group

Professor Evgeny Katz and his team, in collaboration with the Laboratory for Nanobioelectronics (University of California, San Diego) headed up by Professor Joseph Wang, continue to work on the development of ‘sense and treat’ autonomous devices for enhancing the survival rate among soldiers in battlefield conditions by assessing and resolving an injury before proper medical attention is able to reach the injured combatant. The team of students working on this project is headed by Research Assistant Professor Dr. J. Halámek. Over the past year, accomplishments have included the demonstration of scalable multiplexing of twelve clinically-relevant injury biomarkers for the determination of six unique injury conditions. See Figure 4. Moreover the developed, advanced non-invasive textile-based on-body sensors (that are able to withstand the rigors of wear and repeated mechanical stress while preserving their sensitive response) attracted attention from the scientific community. This work was highlighted on the website of the Royal Society of Chemistry (RCS). Dr. Halámek has been invited to deliver keynote presentations and a plenary lecture (describing results of the study) at international symposiums and conferences.  In addition, sufficient progress has been achieved in the fabrication and optimization of advanced signal-responsive actuators for the targeted delivery of medications that are able to respond repeatedly and reversibly to local pH changes and  to other applied stimuli, such as voltage, towards the implementation of the ‘sense and treat’ autonomous operation. This progress was possible because of the fruitful exchange of ideas and collaborative work in the group of undergraduate and graduate students advised by Research Assistant Professor Dr. V. Bocharova. The results of the work were published in prestigious international journals. 

Enzyme based Sensor

Figure 4. UPPER IMAGE: schematic representation of diversity of elements designed using sequence of different enzymatic reactions to mimic key elements of the conventional computing (flip-flop memory, multiplexor/demultiplexor), or to be used as an actuator or controllable interface triggered by enzymatic reactions. BOTTOM IMAGE: schematic representation of the parallel performance of an enzyme- based sensor for the scalable multiplexing of clinically-relevant injury biomarkers for the determination of unique injury conditions.

Besides this project Katz’s group is very active in the field of unconventional computing, where in collaboration with Professor Vladimir Privman (Clarkson University) many key elements of the conventional computer (logic gates, filters, amplifiers, etc.) were mimicked using chemical and biochemical systems. Optimization of the performance of the systems was done through advanced modeling algorithms in order to develop robust and highly reliable architectures with respect to signal-to-noise ratio.

Research conducted in Professor Katz’s group is funded by the Office of Naval Research (ONR), NSF, etc.

Papers describing recent achievements appeared in peer-reviewed journals like Chemical Communications, ACS Applied Materials and Interfaces, Biosensor and Bioelectronics, etc.  The presentation of this research is always appreciated and welcomed at international conferences. This work attracts attention from the press and receives awards. More information about Professor Katz’s research activities can be found at http://people.clarkson.edu/~ekatz/.

Biosensors

Chemistry and Biomolecular Science Professor Silvana Andreescu is working on the development, characterization, and applications of advanced materials for next generation biomedical and biosensing applications for environmental, food, and clinical monitoring. Examples include biomedical sensors for in vivo and in vitro monitoring of clinical analytes, nanoparticle-induced toxicity, and oxidative stress.

In a recent study Professor Andreescu and her group demonstrated that ceria nanoparticles can be used as quantitative chromogenic probes in bioanalysis.  This offers a promising alternative to commonly employed organic dyes. The sensing design takes advantage of changes in the physicochemical and optical properties of ceria nanoparticles in response to the analyte, to create an easy colorimetric readout without additional instrumentation. This study also provides a new nanoparticle platform for the fabrication of paper-based colorimetric bioassays. Of special importance is the fact that the assay does not require the addition of external reagents, because all the sensing components and reagents needed for detection are deposited onto the paper substrate. In addition, the assay shows sensitivity for the detection of physiological glucose concentrations and performs successfully in human serum samples. More information about this work is included in the following reference. Ornatska, Maryna, Sharpe, Erica, Andreescu, Daniel, and Andreescu, Silvana, “Paper Bioassay Based on Ceria Nanoparticles as Colorimetric Probes,” Anal. Chem83, 4273 (2011).

 

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CAMP’s Dr. Dana Barry Wins 16th Consecutive APEX Award and Serves as Visiting Professor in China

Dr. Dana M. Barry

Dr. Dana M. Barry

Dr. Dana M. Barry, senior technical writer and editor at Clarkson University’s Center for Advanced Materials Processing (CAMP), won her 16th consecutive APEX Award for Publication Excellence from Communications Concepts Inc. in Springfield, Va. This honor is based on editorial content and overall communications effectiveness and excellence.  Her winning entry (for 2011) was the CAMP Annual Report Newsletter (2009-2010), which faired extremely well in the competition. There were more than 3,300 entries from the United States and other countries in the competition.  Approximately 957 Awards of Excellence were distributed in 130 subcategories of 11 major areas.

Dr. Barry (a Professor and Scientific Board President for Ansted University) also served as a Visiting Professor and Keynote Speaker in China during the month of September. She delivered the Keynote Address to about 1500 attendees at the International Collaboration Celebration in Xiamen, China. Barry’s talk (a summary of her published work) was titled “Highlights: Promoting Science, Engineering, and Creative Education at the International Level.” At the same event, the World Thinkers’ Panel on the Sustainable Future of Humankind declared its mission for the first time.  Dr. Barry is one of the founding members of the panel. In addition, she presented a paper (“Protect Our Air Which Is Essential for Human Life”) at the First International Conference for Protect the Earth and Ocean at the Xiamen Ocean Vocational College in China.