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CAMP Annual Report: Page 6

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Modeling of the Chemical‑Mechanical Polishing Process

Professors Goodarz Ahmadi and S.V. Babu, in collaboration with the JSR Company, are developing new models for the chemical‑mechanical polishing of low-k materials.  Their analysis includes the influence of abrasive particles and pad surface micro-roughness.   Earlier, Professor Ahmadi and his students studied the effect of abrasive particle shapes, slurry pH, and colloidal forces on the CMP removal rate.

NANOSYSTEMS       

Core-Shell Particles and Fibers for Diverse Applications

CAMP Senior University Professor Richard Partch’s research group applies fundamental chemical and engineering principles to prepare and characterize new generations of core-shell particles having a wide range of industrial applications. Funding from several industrial and government sources is gratefully acknowledged. Currently, the following are some of the topics under investigation:

1)      Preparation and evaluation of filled inorganic and organic composites for better thermal management in electronic devices such as computer/CPU casings, radar domes and thermal diffusion rollers in copy machines.

2)      Determination if catalysis by high surface area dendrimer-shaped metals can enhance the efficiency of already known methods previously researched in the Partch lab for conversion of waste organics into fuel oil. 

3)    Application of pi-pi complex concepts between acceptor molecules tethered to <10nm carrier particles and a wide variety of commonly overdosed therapeutics, illicit narcotics and bio toxins, all of which have donor properties. This project goal is to achieve in vivo deactivation of lethal overdoses that currently have no antidote.

4)   Preparation of particles and fibers having electromagnetic or optical limiting properties for use in wind turbine blades and structures to make them radar stealthy, and as potential bispectral obscurants,

5)    Preparation of DNA and fluorescent labeled particles to stand-off and tamper detection.

6)     Evaluation of chemical and physical methods for removing standard and new biotoner inks from printed paper to improve paper recycling and reduce environmental impact.

  

Clarkson University Team Led By Professor Igor Sokolov Finds Possible New Means of Diagnosing Cancer

Professor Igor Sokolov

Professor Igor Sokolov

A Clarkson University team, led by Physics Professor Igor Sokolov, has found that cancer cells can be identified with very high precision by means of a specific "fractal" analysis of images of a cell’s surface at the nanoscale.

Fractals are “self-similar” irregular shapes that repeat their pattern. These complex disorderly patterns are typically formed under far-from-equilibrium conditions, or emerge from chaos. See Figure 2.

This work was published in the top physics journal Physical Review Letters and selected as one of the "Editors’ Suggestions." It can be found at http://prl.aps.org/abstract/PRL/v107/i2/e028101 .

Fractal

Figure 2. Examples of a fractal and a scanning electron microscopy (SEM) image of a cervical epithelial cell. Zoomed images are shown in the bottom row. The zoomed cell surface was obtained with atomic force microscopy (AFM). A Clarkson University team led by Professor Igor Sokolov has found that cancer cells can be identified with very high precision by means of a specific "fractal" analysis of images of a cell’s surface at the nanoscale.

"Cancerous transformations are associated with chaotic disorganization of many processes in a cell," says Sokolov. "It has been known that fractal behavior can occur in chaotic systems. Fractal behavior was indeed found many decades ago in histological cross-sections of tissues, when tissue becomes cancerous. However, the emergence of fractal behavior at the cellular level had not yet been discovered, but we have finally found it. This may shed light on the nature of cancer from a new physics prospective."
This discovery can potentially be applied to cancer diagnostics. One of the problems in cancer detection is its constant variability, mutations. That is one of the main reasons for the difficulty in segregation of cancerous cells by using biochemical labeling methods.

The Clarkson team is preparing a more detailed description of the results. Also Professor Sokolov and Clarkson Biology Professor Craig D. Woodworth have submitted a proposal for further study to the National Institute of Health. Team members include Sokolov, who has appointments in the Departments of Physics and Chemistry and Biomolecular Science; Woodworth, a cervical cancer expert; Maxim Dokukin, a physics postdoctoral fellow; and physics graduate students Ravi M. Gaikwad (now a postdoctoral fellow at the University of Waterloo) and Nataliia Guz.

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