Sixteen research projects were supported by the Centers for Advanced Technology (CAT) Program of New York State's Office of Science, Technology, and Academic Research (NYSTAR) in the 2001 - 2002 fiscal year. Project titles and principal investigators are listed below for each research area.
Synthesis and Properties
Transport, Deposition and Removal
Dispersions and Processing
Planarization (CMP) Modeling
of Chemical-Mechanical Polishing (CMP)
projects are being funded during 2002-2003.
Thin Films and
CAMP Professors Fendler and Roy Study Nanostructured Layered Materials for Potential Use in Biological and Chemical Sensors
In a collaborative project, CAMP Professors Janos Fendler (CAMP Distinguished Professor of the Chemistry Department) and Dipankar Roy are studying multilayered thin films that are composed of highly ordered nanomaterials. These films are fabricated by using the technique of self-assembly. Molecular self-assembly is now widely recognized as a cost-effective approach to nanofabrication of biomaterials. It often involves relatively simple and well-developed chemical techniques, and at the same time, can provide highly ordered molecular nanostructures that are precisely tailored with desired chemical properties and complex functionalities. Biosensors based on the surface plasmon resonance (SPR) technique utilize these unique features of self-assembled monolayers (SAMs). These SPR sensors (also known as evanescent field sensors) use a densely packed organic SAM (typically 0.5-1.5 nm long, and longer for some proteins), supported by a 40-60 nm thick gold film on an optically transparent solid dielectric substrate as a template for immobilized bio-recognition molecules (sensing element). The CAMP groups are studying how such self-assembled structures can be modified in a precisely controlled manner to further improve the performance of currently existing SPR sensors, as well as to develop new classes of sensors.
Professors Fendler and Roy have demonstrated the potential for an SPR sensor that uses an ionizable acidic SAM in its detection element. Such a sensor would respond to the acidity (pH-level) of a liquid environment, and can be used to develop a novel (optical) titration technique for acidic SAMs. Recent measurements also indicate that under certain experimental conditions, the analyte-detection efficiency of a commonly used SPR biosensor can be substantially enhanced by the incorporation of gold or silver nanoparticles (~10-25 nm in diameter) in its sensing element. Refer to Lyon et al., Anal. Chem., 70, 5177 (1998). In order to control, utilize and tailor this remarkable feature of nanoparticle-based SPR imaging, it is first necessary to characterize in detail the underlying mechanism(s) of SPR enhancement in the presence of metal nanoparticles in the sensing device. During 2001-02, the CAMP groups led by Professors Fendler and Roy have made considerable progress toward a quantitative clarification of this problem. They have shown that the nanoparticle-induced enhancement of SPR detection results from certain interfering effects of localized surface plasmons in the nanoparticles and propagating plasmon polaritons in the gold substrate film of the sensor. These findings are reported in a series of recent publications coauthored by Professors Fendler and Roy with their research group members. The theoretical framework used to analyze the optical response of nanoparticle-based SPR sensors has been discussed in two of Professor Roy's papers.
Research in this area by the CAMP groups is continuing, and it is expected that the new results will considerably ease the difficult task of designing nanoparticle-based high performance SPR biosensors. Currently Professors Fendler and Roy are attempting to combine FFT-EIS with the SPR technique. Their goal is to eventually achieve new types of opto-electrochemical biosensors that would have much broader capabilities than the currently available sensors based on single detection methods. Complete lists of recently published research reports from Professors Fendler's and Roy's groups can be found at the following web sites: www.clarkson.edu/~janoslab www.clarkson.edu/~samoy/pub.htm For information about Professor Fendler and his research, you may call him at 315-268-7113 or send e-mail to firstname.lastname@example.org. For information about Professor Roy and his research, you may call him at 315-268-6676 or send e-mail to email@example.com.