CAMP March Newsletter: Page 7
CAMP Professor Cetin Cetinkaya Uses Contact Ultrasonic Techniques to Characterize the Mechanical and Geometric Properties of Dry-Coated Tablets
Figure 3. A photograph of a dry-coated (tablet-in-tablet) with its subcomponents.
A one-step dry-coated tablet is a solid dosage form with a controlled drug-release system, which consists of a core and an outer layer. See Figure 3. CAMP Professor Cetin Cetinkaya and his group (in the Photo-Acoustics Research Laboratory at Clarkson) have developed a set of methods to characterize various components of dry-coated tablets. The accuracy of a tablet's geometric (e.g. the outer layer wall and core thicknesses) and mechanical properties (e.g. Young's moduli and mass densities of associated materials) could be crucial to its therapeutic and structural functions. The objective of Professor Cetinkaya's current study is to develop a non-destructive technique for determining the geometric and mechanical properties of dry-coated tablets. Two contact ultrasonic techniques (pitch-catch and pulse-echo measurement modes) are being used to measure and report the properties of all the structural components of a set of experimental tablets. The thicknesses of the outer layers of the sample tablets are used to obtain the eccentricity of the core tablets. The two approaches are then compared in regards to their effectiveness in obtaining these properties of the sample dry-coated tablets. Professor Cetinkaya is also using his new proposed approach to determine the thicknesses of the outer layers. His new approach results are being compared to those of the direct (destructive) method. A good agreement has been found because there is only about a 2% difference. Cetinkaya's new approach has potential for in-die real-time monitoring of compaction presses and for applications in pharmaceutical manufacturing.
CAMP's Outreach Expanded
CAMP Professor Richard Partch has been invited by the American Chemical Society (ACS) to offer his popular Short Course "Particle Surface Modification for Improving Properties and Applications" at the fall 2010 National ACS Meeting in Boston.
Also his name has been added to the ACS National Tour Speaker list, to give presentations on the following topics.
1) Nanoparticles for Cancer and Chemical Overdose Therapies
2) Aerosol and Liquid Dispersions for Particle Surface Modification
3) Sandpaper, Toothpaste and Computer Chips: What Do They Have in Common?