Silvana Andreescu

Assistant Professor
Chemistry
206 Science Center
Clarkson University
PO Box 5810
Potsdam, NY 13699-5810

Phone: 315-268-2394
E-mail: eandrees@clarkson.edu

Department Web site
Research Web site

Educational Background:
Ph.D. University of Bucharest, Bucharest, Romania (Analytical Chemistry)
Ph.D. University of Perpignan, Perpignan, France (Agrochemistry)
Postdoctoral Fellowship, State University of New York at Binghamton

Research Interests:
Our work lies in three main directions: microencapsulation techniques, bioremediation and biosensors. We are currently investigating the use of natural biopolymers in conjunction with nanoparticle based hybrid materials for the development of polymeric microcapsules with application in drug-delivery and bioremediation. We are focused on increasing the stability of the microcapsules and studying the time-released mechanism. We are also investigating the potential use of these systems for the encapsulation of biological material (cells and enzymes) for the construction of bioreactors. This will have application in catalytic processes in biotechnology and for the removal of organic pollutants from environmental matrices. In the field of biosensors, we are investigating new biomaterials for the purpose of increasing the selectivity and the stability of these devices.

Selected Publications:
S. Andreescu, J.-L. Marty, Twenty years research in cholinesterase biosensors: From basic research to practical applications, Biomolecular Engineering (A review-invited contribution), 23 (1), 2006, 1-15.

S. Andreescu, B. Bucur, J.-L. Marty, Affinity Immobilization of Tagged Enzymes in  Immobilization of Enzymes and Cells, second edition, Ed. by J.M. Guisan, Series: Methods in Biotechnology, Humana Press, March 2006 (ISBN: 1-59745-053-7).

M. Campas, S. Andreescu, T. Noguer, J.-L. Marty, Screen-printed electrode biosensors, in Biosensors: Methods Express, Scion Publishing Ltd., In press, August 2006 (ISBN: 1904842127). S. Andreescu, O.A. Sadik, Advanced Electrochemical Sensors for Cell Cancer Monitoring, Methods, 37, 2005, 84-93.

J. Karasinski, S. Andreescu, O.A. Sadik, B. Lavine, Vora, M.N., Multiarray Sensors with Pattern Recognition for the Detection, Classification and Differentiation of Bacteria at Species and Subspecies Levels, Anal. Chem., 77 (24), 2005, 9741-7949.

S. Andreescu, D.W. McGee, O.A. Sadik, Effect of Natural and Synthetic Estrogens on A549 Lung Cancer Cells: Correlation of Cytotoxic Effects to Chemical Structures, Chem. Res. Toxicol. 18, 2005, 446-474.

S. Andreescu, O.A. Sadik, D.W. McGee, S. Suye, Autonomous Multielectrode System for Monitoring the Interactions of Isoflavonoids with Lung Cancer Cells, Anal. Chem. 76, 2004, 2321-2330.

S. Andreescu, O.A. Sadik, The Correlation of Analyte Structures with Biosensor Responses using Structure-Activity Relationship: Detection of Phenolic Estrogens as Model, Anal. Chem. 76, 2004, 552-560.

S. Andreescu, O.A. Sadik, Trends & Challenges in Biochemical Sensors for Clinical and Environmental Monitoring, Pure Appl. Chem. 76(4), 2004, 861-878.

O.A. Sadik, A.K. Wanekaya, S. Andreescu, Advances in Analytical Technologies for Environmental Protection and Public Safety, J. Environ. Monit. (Critical review) 6, 2004, 413-522.

S. Andreescu, D. Andreescu, O.A. Sadik, A new electrocatalytic mechanism for the oxidation of phenols at platinum electrodes, Electrochem. Commun. 5(8), 2003, 681-688.

S. Andreescu, L. Barthelmebs, J.-L. Marty, Immobilisation of AChE on screen-printed electrodes; Comparative study between three immobilisation methods; Applications to the detection of organophosphorus insecticides, Anal. Chim. Acta 464, 2002, 171-180.

S. Andreescu, T. Noguer, V. Magearu, J.-L. Marty, Screen-printed electrode based on AChE for the detection of pesticides in presence of organic solvents, Talanta 57, 2002, 169-176.

S. Andreescu, A. Avramescu, C. Bala, V. Magearu, J.-L. Marty, Detection of organophosphorus insecticides with immobilized acetylcholinesterase: Comparative study between two enzyme sensors, Anal. Bioanal. Chem. 374, 2002, 39-45.

S. Andreescu, V. Magearu, A. Lougarre, D. Fournier, J.-L. Marty, Immobilization of enzymes on screen-printed sensors via an histidine tail. Application to the detection of pesticides using modified cholinesterase, Anal. Lett. 34(4), 2001, 429-540.