Distinguished Emeritus Professor
Chemistry & Biomolecular Science
129 Science Center
PO Box 5810
Potsdam, NY 13699-5810
RNDr. Charles University, Prague - Organic Electrochemistry, Physical Organic Chemistry
Mechanisms of some organic reactions are investigated using polarographic, voltammetric, and kinetic measurements. Examples of recently studied reactions are: Acid-base, hydration-dehydration and tautomeric equilibria involving 1,3,5- and 1,2,4-triazines, selenous acid and mytomicin C, reactions of bile acids, cholesterol, and other sterols in strongly acidic media, additions of nucleophiles, such as glutathione, to nitrosobenzene, etc. Most of these studies involve biologically important compounds and their investigations are essential both for development of analytical methods and for their contribution to a better understanding of biological activity.
Another active area are studies of electroreduction and electrooxidation of some organic compounds, such as aromatic nitrocompounds, various pesticides including maleic hydrazide, 1,3,5- and 1,2,4-triazines, selenous acid, mitomycin C, phenols, etc. Structure-reactivity relationships are investigated, for example the transfer of electronic effects through an N-N single bond, ring formation of some 2-amino-1,4-benzoquinones, or interactions between two reducible groups in a molecule. Polarographic reduction of pesticides has been used to study their adsorption on lignin, to determine their bioavailability in applications in forest nurseries. Studies of alkaline cleavage of lignin at room temperature will form a basis for the use of lignin (which is a renewable raw material) for future industrial applications