Chemistry & Biomolecular Science
135 Science Center
PO Box 5810
Potsdam, NY 13699-5810
1988 B.Sc. & M.Sc. in Chemical Engineering- D.I. Mendeleyev Chemical Engineering Univ., Moscow, Russia
1997 Ph.D. in Organic Chemistry- Weizmann Institute of Science, Rehovot, Israel
|2008-present||Associate Professor, Department of Chemistry & Biomolecular Science, Clarkson University, Potsdam, NY|
|2007-2008||Research Fellow, National Institute of Diabetes, Digestive & Kidney Diseases, National Institutes of Health, Bethesda, MD|
|1999-2006||Lecturer, Hebrew University of Jerusalem, Jerusalem, Israel|
|1997-1999||Postdoctoral Associate, Dyson-Perrins Laboratories, University of Oxford, Oxford, UK|
Anticancer iron chelators, small molecules capable of chelating iron in cancer cells stopping their growth and causing apoptosis
Dynamic self-assembly through complementary metal complexes based on selective binding of two different tridentate chelate ligands into octahedral heteroligand complexes
Semisynthetic macrolide antibiotics capable of inhibiting protein synthesis in MLSB resistant bacteria
Amplified responsive systems capable of changing their macroscopic properties triggered by detection of substoichiometric amounts of analytes
Treatments of iron overload diseases through chelation of iron
Research Publications (last 3 years)
Bruchet, M.; Mendelson, N.; Melman, A., Photochemical patterning of ionically cross-linked hydrogels Processes 2013, 1, 153-166.
Liu, X. X.; Melman, A., Templated alkylation of hexahistidine function with Baylis-Hillman esters, Chem. Commun. 2013, in print, DOI: 10.1039/C3CC43271H.
Penta, N. K.; Peethala, B. C.; Amanapu, H. P.; Melman, A.; Babu, S. V., Role of hydrogen bonding on the adsorption of several amino acids on SiO2 and Si3N4 and selective polishing of these materials using ceria dispersions Colloids and Surfaces A: Physicochemical and Engineering Aspects 2013, 429, 67-73.
Melman, G.; Bou-Abdallah, F.; Vane, E.; Maura, P.; Arosio, P.; Melman, A., Iron release from ferritin by flavin nucleotides Biochimica et Biophysica Acta (BBA) - General Subjects 2013, 1830, 4669–4674.
Liu, X. X.; Melman, A., Formation of ternary complexes of iron(III) cations in solution and gas phase Aust. J. Chem. 2013, , 66, 791-797.
Narayanan, R. P.; Melman, G.; Letourneau, N. J.; Mendelson, N. L.; Melman, A., Photodegradable Iron(III) Cross-Linked Alginate Gels Biomacromolecules 2012, 13, 2465-2471.
LeTourneau, N.; Vimal, P.; Klepacki, D.; Mankin, A.; Melman, A., Synthesis and antibacterial activity of desosamine-modified macrolide derivatives Bioorg. Med. Chem. Lett. 2012, 22, 4575-4578.
Jin, Z. Y.; Guven, G.; Bocharova, V.; Halamek, J.; Tokarev, I.; Minko, S.; Melman, A.; Mandler, D.; Katz, E., Electrochemically Controlled Drug-Mimicking Protein Release from Iron-Alginate Thin-Films Associated with an Electrode ACS Applied Materials & Interfaces 2011, 4, 466-475.
Bou-Abdallah, F.; McNally, J.; Liu, X. X.; Melman, A., Oxygen catalyzed mobilization of iron from ferritin by iron(III) chelate ligands Chem. Commun. 2011, 47, 731-733.
Patents (last 3 years)
Melman, A. "Method for selective derivatization of oligohistidine sequence of recombinant proteins", US Patent submitted on 2013-08-08
Melman, A. "Cross-Linked Polymer Based Hydrogel Material Compositions, Methods And Applications" US2012288479 (A1) 2012-11-15
Current Graduate Students
- Marion Bruchet, expected Ph.D. 2016. Research topic: Responsive ionically cross-linked hydrogels
- Nicolas LeTourneau, expected Ph.D. 2015. Research topic: Site selective derivatization of recombinant proteins.
- Xing Xing Liu, expected Ph.D. 2014. Research topic: Complementary coordination bonding and its practical applications.
- Pavan Vimal. MSc. 2012– currently Staff Associate Investigator at DuPont Bethlehem, Pennsylvania. Thesis title: Chemo- and stereoselective modification of hydroxyl groups for synthesis of conformationally restricted biologically active compounds.