Silvana Andreescu, PhD
Professor and Egon Matijević Chair
Department of Chemistry and Biomolecular Science, Clarkson University
Phone: 315-268 2394; Fax: 315-268 6610
NATO-NSF Postdoctoral Fellowship, State University of New York at Binghamton
Ph.D. Chemistry, University of Perpignan, France and University of Bucharest, Romania
MS Biosensors, University of Bucharest, Romania
BS Chemistry, University of Bucharest, Romania
- Research Excellence Award, Clarkson University, 2014
- John W. Graham Jr. Faculty Research Award, Clarkson University, 2011
- NSF-CAREER award, National Science Foundation (NSF), 2010
- Invited professor, Technological Institute, University of Perpignan, Perpignan, France, 2007
- NSF-NATO postdoctoral fellowship award, NSF, 2003–2004
- EGIDE-CNRS Research Scholarship, France, 2002
- European Community, BIOSET Collaboration Program: Environment and Climate, 2000
- BGF - French Government Doctoral Scholarship, University of Perpignan, France, 1999–2002
- Doctoral Scholarship: University of Bucharest, Faculty of Chemistry, Romania, 1999–2002
- European Community, TEMPUS-MS fellowship: Biosensors for Environmental Control, 1998
Our research is in the field of analytical and bioanalytical chemistry focusing on investigations of basic biochemical mechanisms at biointerfaces, bionanotechnology, biomimetic materials and artificial receptors, and the development of novel analytical methods and instrumentation to address current and emerging problems of clinical and environmental significance. Sensors developed in our laboratory are used to understand fundamental molecular mechanisms in biological systems, determine clinically important analytes associated with medical conditions and address environmental challenges. Examples of current projects include: (1) low cost field portable sensors for toxicity monitoring, (2) redox active nanoparticles for switchable biomolecular assays, (3) implantable electrochemical microelectrodes for studying neurotransmission in the zebrafish model system, (4) microelectrochemical probes for quantitative assessment of oxidative stress and understanding the relationship between oxidative stress and nanoparticle exposure, (5) development of methods for in situ characterization of nanoscale materials and understanding of the chemical transformation of engineered nanoparticles in the environment, (6) electrochemical collision technique for single particle characterization of the nanoparticles’ surface properties, catalytic activity and chemical reactivity and (7) study of single particle biomolecular recognition events at bioconjugated nanoparticles for ultrasensitive detection of molecular targets.
Recent Peer Reviewed Publications (selection)
N.P. Sardesai, M. Ganesana, A. Karimi, JC. Leiter, S. Andreescu, Platinum-Doped Ceria Based Biosensor for in Vitro and in Vivo Monitoring of Lactate during Hypoxia, Anal. Chem. 87, 2015, 2996-3003.
A. Karimi, A. Othman, , A. Uzunoglu, L. Stanciu, S. Andreescu, Graphene based Enzymatic Bioelectrodes and Biofuel Cells, Nanoscale, 7, 2015, 6909-6923.
N.P. Sardesai, A. Karimi, S. Andreescu, Engineered Pt doped nanoceria for oxidase based bioelectrodes operating in oxygen deficient environment, ChemElectrocChem, 1, 2014, 2082-2088 (cover page).
D. Andreescu, G. Bulbul, E. R. Ozel, A. Hayat, N.P. Sardesai, S. Andreescu, Applications and Implications of Nanoceria Reactivity: Measurement Tools and Environmental Impact, Environ. Sci.: Nano 1, 2014, 445-458.
E. Sharpe, S Andreescu, Integration of Nanoparticle Based Paper Sensors into the Classroom: an Example of Application for Rapid Colorimetric Analysis of Antioxidants, J. Chem Educ. 92, 2015, 886-891.
E. R. Ozel, X. Liu, R. Alkasir, S. Andreescu, Electrochemical methods for nanotoxicity assessment, Trends in Analytical Chemistry 59, 2014, 112-120.
A. Hayat, G. Bulbul, S. Andreescu Probing phosphatase activity using redox active nanoparticles: a novel colorimetric approach for the detection of enzyme activity, Biosens. Bioelectron. 56, 2014, 334-339.
E. Sharpe, B. Bradley, T. Fresco, D. Jayathilaka, A. Marsh, S. Andreescu, Metal oxide based multisensor array and portable database for field analysis of antioxidants, Sensors & Actuators: B. Chemical 193, 2014, 552-562.
A. Hayat, D. Andreescu, G. Bulbul, S. Andreescu, Redox reactivity of cerium oxide nanoparticles against dopamine, J. Colloid Interface Science 418, 2014, 240-245.
N. P. Sardesai, D. Andreescu, S. Andreescu, Electroanalytical evaluation of antioxidant activity of cerium oxide nanoparticles by nanoparticle collisions at microelectrodes, J. Am Chem. Soc. 135, 2013, 16770-16773.
E. R. Ozel, K. Wallace, S. Andreescu, Alterations of intestinal serotonin following nanoparticle exposure in embryonic zebrafish., Environmental Science: Nano 1, 2014, 27-36.
A. Hayat, S. Andreescu, Nanoceria particles as catalytic amplifiers for alkaline phosphatase assays, Anal. Chem. 85, 21, 2013, 10028-10032.
E. R. Ozel, A. Hayat, K. Wallace, S. Andreescu, Effect of cerium oxide nanoparticles on intestinal serotonin in zebrafish, RSC Advances 3, 2013, 5298-15309.
E. R. Ozel, R. Alkasir, K. Ray, K. Wallace, S. Andreescu, Comparative Evaluation of Intestinal Nitric Oxide in Embryonic Zebrafish Exposed to Metal Oxide Nanoparticles, Small 9, 24, 2013, 4250-4261.
E. Sharpe, T. Fresco, D. Andreescu, S. Andreescu, Portable nanoparticle based technology for rapid detection of food antioxidants (NanoCerac), Analyst 138, 1, 2013, 249-262.
R.S.J. Alkasir, M. Ornatska, S. Andreescu, Colorimetric paper bioassay for the detection of phenolic compounds, Anal. Chem. 84, 2012, 9729-9737.
M. Ganesana, J.S. Erlichman, S. Andreescu, Real-time monitoring of superoxide accumulation and antioxidant activity in a brain slice model using an electrochemical cytochrome c biosensor, Free Radical Biology & Medicine 53, 2012, 2240-2249.
M. Ornatska, E. Sharpe, D. Andreescu, S. Andreescu, Ceria nanoparticles as colorimetric probes in paper-based bioassays, Anal. Chem. 83 (11), 2011, 4273–4280.
E. R. Ozel, K. Wallace, S. Andreescu, Chitosan functionalized carbon fiber microelectrodes for real-time in vivo detection of neurotransmitters in live embryonic zebrafish, Anal. Chim. Acta 695, 2011, 89–95.
J. Njagi, M. Chernov, J. Leiter, S. Andreescu, Amperometric detection of dopamine in vivo with an enzyme based carbon fiber microbiosensor, Anal. Chem. 82 (3), 2010, 989–996.
A. R. Alkasir, M. Ganesana, Y.H. Won, L Stanciu, S. Andreescu, Enzyme functionalized nanoparticles for electrochemical biosensors: a comparative study with applications for the detection of bisphenol A, Biosens. Bioelectron. 26, 2010, 43-49.
J. Njagi, M. Ball, K. Wallace, S. Andreescu. Electrochemical quantification of serotonin in the live embryonic zebrafish intestine, Anal. Chem. 82 (5), 2010, 1822-1830.
C. Ispas, M. Ravalli, A. Steere, S. Andreescu, Biomagnetic capsules for easy removal of phenol and bisphenol A, Water Research 44, 2010, 1961–1969.
C. Ispas, D. Andreescu, A. Patel, D. Goia, S. Andreescu, K. Wallace, Toxicity and developmental defects of different sizes and shape nickel nanoparticles in zebrafish. Environ. Sci. Technol. 43, 16, 2009, 6349-6356.
C. Ispas, I. Sokolov, S. Andreescu, Enzyme functionalized mesoporous silica for bioanalytical applications, Anal. Bioanal. Chem. 393, 2, 2009, 543-554.
J. Njagi, C. Ispas, S. Andreescu, Mixed Ceria Based Metal Oxides Biosensor for Operation in Oxygen Restrictive Environments, Anal. Chem. 80, 2008, 7266-7274.
C. Ispas, J. Njagi, M. Cates, S. Andreescu, Electrochemical Studies of ceria as electrode material for sensing and biosensing applications, J. Electrochem. Soc. 155(8), 2008, 169-176.
S. Andreescu, L.A. Luck, Studies of the Binding and Signaling of Surface-immobilized Periplasmic Glucose Receptors on Gold Nanoparticles: A Glucose Biosensor Application, Anal. Biochem. 375, 2008, 282-290.
J. Njagi, S. Andreescu, Stable enzyme biosensors based on chemically synthesized Au-polypyrrole nanocomposite, Biosens. Bioelectron. 23, 2, 2007, 768-775.
Nanotechnology for Environmental Decontamination, McGraw-Hill (ISBN 0071702792), Ed: M.K. Ram, S. Andreescu, H. Ding, 448 pages, May, 2011.
Oxidative Stress: Diagnostics, Prevention, and Therapy, American Chemical Society Symposium Series, Oxford University Press (ISBN13: 9780841226838). Ed: S. Andreescu, M. Hepel, Volume 1083, 428 pages, November 17, 2011.
E.S. Andreescu, M. Ornatska, C. Ispas, D. Andreescu, Reagentless ceria based colorimetric sensor: colorimetric components, methods of use, methods of assembly and related applications, Patent Application, US20120315659, WO2012170851A3, Publication date: December 13, 2012.
E.S. Andreescu, E. Sharpe, D. Andreescu, Portable nanoparticle based assay for rapid detection of food antioxidants (NANOCERAC), US 20140162368 A1 , Publication date, June 2014.
Current Research Group Personnel
Research Associates, Postdoctoral Fellows and Visiting Faculty
- Dr. Akhtar Hayat
- Dr. Dinusha P. Karunaratne
Current Graduate Students
- Xiaobo Liu
- Gonca Bulbul
- Anahita Karimi
- Eduard Dumitrescu
- Ali Othman
- Ramiz Alkassir